Human Growth Hormone Playing An Anabolic Role In The Body
Below is a MRR and PLR article in category Health Fitness -> subcategory Supplements.
Human Growth Hormone: An Anabolic Force in the Body
Introduction
Human Growth Hormone (HGH), also known as somatotropin, is a protein hormone composed of 190 amino acids. It is produced and secreted by the somatotroph cells in the anterior pituitary gland. The genes responsible for HGH are located in the q22-24 region of chromosome 17. HGH's structure includes four helices necessary for interaction with growth hormone (GH) receptors. It shares structural similarities with prolactin and chorionic somatomammotropin, suggesting evolutionary connections. This group of hormones promotes growth and influences lactogenic activity.
Human Growth Hormone Secretion
The secretion and synthesis of HGH are influenced by various factors, including exercise, nutrition, sleep, and stress. Regulation is primarily controlled by two hypothalamic hormones?"Growth Hormone-Releasing Hormone (GHRH) and Somatostatin (SS)?"as well as Ghrelin from the stomach.
Functions of HGH
HGH plays a crucial role in building the human body through both direct and indirect effects on tissues:
1. Direct Effects: HGH binds to receptors on target cells to exert immediate effects.
2. Indirect Effects: HGH stimulates the release of Insulin-like Growth Factor-I (IGF-I) from the liver and other tissues. Most growth-promoting effects of HGH are due to IGF-I acting on cells.
HGH and Growth
HGH's primary role in body growth is to stimulate the liver and other tissues to produce IGF-I. IGF-I promotes the proliferation of chondrocytes (cartilage cells), leading to bone growth.
HGH and Metabolism
HGH significantly impacts protein, lipid, and carbohydrate metabolism. Some of these effects are direct, while others are indirect, with a few showing mixed actions. Beyond promoting height growth, HGH supports protein synthesis, muscle mass development, calcium retention, bone mineralization, immune system stimulation, and fuel homeostasis maintenance.
Modern Applications
Biosynthetic human growth hormone, known as recombinant human growth hormone (rHGH), was first used therapeutically in the U.S. in 1985. This synthetic form has largely replaced natural pituitary-derived HGH in medical treatments.
In summary, HGH is vital for numerous physiological processes, particularly in growth and metabolism, making it an essential hormone for human development and health.
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