Aromasin-Exemestane A Steroidal Suicide Aromatase Inhibitor
Below is a MRR and PLR article in category Health Fitness -> subcategory Other.
Aromasin-Exemestane: A Comprehensive Overview
Summary:
Aromasin-Exemestane is an innovative treatment designed to reduce estrogen production by targeting the aromatase enzyme. It was primarily developed for postmenopausal women battling breast cancer, especially for those who haven't responded effectively to initial treatments like SERMs (e.g., Tamoxifen). Aromasin-Exemestane is notably more potent than many other options used in breast cancer management.
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Article Body:
Aromasin-Exemestane is a steroidal aromatase inhibitor that effectively decreases estrogen levels by inhibiting the aromatase enzyme, key in estrogen synthesis. This drug is particularly useful for postmenopausal women with estrogen-receptor positive early breast cancer, who require a more aggressive therapeutic approach.
Typically prescribed for a period of 2 to 3 years, this therapy often follows Tamoxifen as part of a comprehensive 5-year adjuvant treatment plan. Aromasin-Exemestane serves as a non-reversible, steroidal aromatase inactivator and is chemically similar to androstenedione, a naturally occurring substrate. It functions by permanently binding to and deactivating the enzyme, a mechanism known as suicide inhibition.
Aromasin-Exemestane significantly reduces estrogen levels in postmenopausal women without affecting the production of corticosteroids or aldosterone from the adrenal glands. Moreover, it does not interfere with other enzymes involved in steroidogenesis, even at concentrations much higher than those required to inhibit aromatase.
Common Side Effects:
Some common side effects include hot flashes, upset stomach, fatigue, nausea, increased sweating and appetite, acne, water retention, insomnia, and joint pain. There's also a potential for decreased bone mineral density over time, as evidenced by some cases of osteoporosis and fractures in the AROMASIN IES study participants.
Dosage and Ingredients:
Aromasin-Exemestane tablets contain 25 mg of exemestane. The inactive ingredients include microcrystalline cellulose, methylparaben, sodium starch glycolate, and several others, ensuring the pill's effectiveness and stability.
Important Considerations:
- Not to be used during pregnancy.
- Only suitable for postmenopausal women.
- Should not be combined with medications containing estrogen.
Patients should discuss their medical history and any other medications or supplements with their healthcare provider before starting Aromasin-Exemestane to ensure optimal safety and efficacy.
You can find the original non-AI version of this article here: Aromasin-Exemestane A Steroidal Suicide Aromatase Inhibitor.
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