Diabetes Alzheimer s and Diabetes Could Be Linked Diseases II
Below is a MRR and PLR article in category Health Fitness -> subcategory Disease Illness.
Diabetes, Alzheimer's, and Their Potential Connection
Summary:
Researchers at Brown University Medical School explored insulin function and its receptors in the frontal brain region, significantly impacted by Alzheimer's disease.Article:
A team at Brown University Medical School investigated how insulin and its receptors function in the frontal brain, an area notably affected by Alzheimer's. They discovered that as Alzheimer's severity advances, the levels of insulin receptors and the brain's response to insulin decline markedly.Experts noted that in the most advanced stages of Alzheimer's, insulin receptors were reduced by nearly 80% compared to a normal brain. Additionally, two significant abnormalities related to insulin in Alzheimer's were identified. First, insulin levels drop as the disease progresses. Second, both insulin and insulin-related growth factor-I lose their ability to bind effectively to cell receptors, creating resistance to these growth factors. This resistance leads to cell malfunction and death.
Suzanne M. de la Monte, a neuropathologist at Rhode Island Hospital and professor at Brown University, highlighted that insulin impairment appears early in Alzheimer's and is linked to critical neurotransmitters responsible for cognition.
Furthermore, their findings reveal links between insulin issues and poor energy metabolism, as well as abnormalities contributing to the tangles associated with advanced Alzheimer's. This study connects several concepts, suggesting that Alzheimer's could potentially be seen as a Type 3 diabetes, explained de la Monte, the research leader.
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